Quav Cawv Dehydrogenase Hauv Lub Siab

Cawv dehydrogenase nyob rau hauv daim siab yog lub luag haujlwm rau oxidizing ethanol (ib qho ua ntawm cawv) rau acetaldehyde, thiab cov txiaj ntsig acetaldehyde yog siv los ua cov txheej txeem ua kom hloov mus rau cov tsis muaj teebmeem acetic acid (ib feem ntawm cov kua qaub) nyob rau hauv catalysis ntawm acetaldehyde dehydrogenase. Acetaldehyde muaj tshuaj lom ntau dua li ethanol thiab yog ib qho ua rau lub hauv paus rau kev tuag. Ntxiv mus, acetaldehyde xav tias yog neeg tua kabmob, thiab nws muaj qee yam kev sib raug zoo nrog qhov tshwm sim ntawm tib neeg cov qog. Nws yog acetaldehyde dehydrogenase (ALDH) hauv lub siab uas ua lub luag haujlwm rau kev hloov pauv ntawm acetaldehyde hauv tib neeg. Qhov raug raws li ntawm ALDH1 thiab ALDH2 txawv heev. K_M ntawm ALDH2 rau acetaldehyde yog qis dua li ntawm ALDH1, uas yog li 1 / ntawm tom kawg. 10, yog isoenzyme lub luag haujlwm tseem ceeb rau kev hloov pauv ntawm acetaldehyde.