Ricin Tus Qauv

Ricin (suav txog li 5% ntawm ricin, nrog rau ib lub cev hnyav txog li 66 kD) yog hom II heterodimeric ribosome inactivating protein, uas yog muaj li ntawm ribosome inactivating enzymes (ricin A saw) thiab ib nrab Lactose / N-acetylgalactosamine yog tsim ntawm cov lus qhuab qhia (kab hlau ricin B) tshwj xeeb ua txhua yam, thiab daim ntawv xev disulfide tau txuas nrog ob. Kev ntsuam xyuas ntawm cov qauv pib ntawm ricin pom tias txoj saw A muaj 267 amino acid seem nrog cov molecular hnyav li 32 kD. Nws muaj cov kev ua catalytic thiab yog cov saw effector ntawm cov protein ntau. Ib qho lysine (Lys) qhov seem muaj nyob rau hauv txoj haujlwm 4 ntawm N-davhlau ya nyob twg thiab C-davhlau ya nyob ntawm A saw, uas yog qhov chaw tseem ceeb ntawm kev ua kom muaj kuab lom ntawm ricin A saw. Txoj saw B muaj 2 thawj, 2 tus thawj no muaj homology thiab raug tsim tawm los ntawm kev luam theej tawm cov noob. No 1 muaj cov amino terminus, thaum sau 2 muaj lub carboxy terminus. Ricin B saw yog li ntawm 267 amino acid seem thiab muaj qhov khi ntawm kev ua haujlwm. Nws yog txoj saw hlau muaj sia.